Below is a list of recent publications in which students of our DTP have been involved. The complete list can be found in the left panel of this page.
O’Sullivan, E.A., Wallis, R., Mossa, F. et al. The paradox of senescent-marker positive cancer cells: challenges and opportunities. npj Aging 10, 41 (2024). https://doi.org/10.1038/s41514-024-00168-y
Carr, L., Norris, K., Parker, H., Nilsson-Takeuchi, A. et al. Telomere length and DNA methylation epitype both provide independent prognostic information in CLL patients; data from the UK CLL4, ARCTIC and ADMIRE clinical trials. Br J Haematol (2024). https://doi.org/10.1111/bjh.19765
Graham LV, Fisher JG, Doyle ADP, Sale B, Del Rio L, French AJE, Mayor NP, Turner TR, Marsh SGE, Cragg MS, Forconi F, Khakoo SI and Blunt MD. KIR2DS2+ NK cells in cancer patients demonstrate high activation in response to tumour-targeting antibodies. Front. Oncol. (2024). 14:1404051. doi: 10.3389/fonc.2024.1404051
Bell, J.A., Davies, E.R., Brereton, C.J., et al. Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2, Cell Reports Medicine 5, 9 (2024). https://doi.org/10.1016/j.xcrm.2024.101695
Hill BR, Ozgencil M, Buckley-Benbow L, Skingsley SLP, Tomlinson D, Eizmendi CO, Agnarelli A, Bellelli R. Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors. Cell Rep. 2024 May 28;43(5):114205. doi: 10.1016/j.celrep.2024.114205.
Dontamsetti KD, Pedrosa-Suarez LC, Aktar R, Peiris M. Sensing of luminal contents and downstream modulation of GI function. JGH Open. 2024 May 22;8(5):e13083. doi: 10.1002/jgh3.13083.
Guscott, M.A., McClelland, S.E. Experimental evolution of cancer chromosomal changes. Nat Genet (2024). https://doi.org/10.1038/s41588-024-01742-6
Graham LV, Fisher JG, Khakoo SI, Blunt MD. Targeting KIR as a novel approach to improve CAR-NK cell function. Journal of Translational Genetics and Genomics. 2023; 7(4): 230-5. http://dx.doi.org/10.20517/jtgg.2023.25
Andrade, J.R., Gallagher, A.D., Maharaj, J. et al. Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies. Chromosome Res 31, 28 (2023). https://doi.org/10.1007/s10577-023-09737-5
Fisher, J.G., Doyle, A.D.P., Graham, L.V. et al. XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression. Leukemia 37, 2036–2049 (2023). https://doi.org/10.1038/s41375-023-01984-z
Lawrence, R., Watters, M., Davies, C.R. et al. Circulating tumour cells for early detection of clinically relevant cancer. Nat Rev Clin Oncol 20, 487–500 (2023). https://doi.org/10.1038/s41571-023-00781-y
Sirvent, S., Vallejo, A.F., Corden, E. et al. Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis. Nat Commun 14, 2880 (2023). https://doi.org/10.1038/s41467-023-38588-1
Relton, E.l., Roth, N.J., Yasa, S., Lefrancois, S., McCormick, P.J., Locker, N. et al. The Batten disease protein CLN3 is important for stress granules dynamics and translational activity. Journal of Biological Chemistry 299, 104649 (2023). https://doi.org/10.1016/j.jbc.2023.104649
Look A, Burns D, Tews I, Roghanian A and Mansour S (2023) Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes. Front. Immunol. 14:1176724. doi: 10.3389/fimmu.2023.1176724
Tovini, L., Johnson, S.C., Guscott, M.A. et al. Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies. The EMBO Journal 42: e11158 (2023). https://doi.org/10.15252/embj.2022111587
Monahan, K.J, Swinyard. O., Latchford, A. Biology of Precancers and Opportunities for Cancer Interception: Lesson from Colorectal Cancer Susceptibility Syndromes. Cancer Prev Res (Phila) 1 August 2023; 16 (8): 421–427. https://doi.org/10.1158/1940-6207.CAPR-22-0500
Higgins, L., Gerdes, H., Cutillas, P. R.; Principles of phosphoproteomics and applications in cancer research. Biochem J 29 March 2023; 480 (6): 403–420. doi: https://doi.org/10.1042/BCJ20220220
Tomas-Bort, E., Joseph, M.D., Wang, Q. et al. Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion. eLife 12:e86971 (2023) . https://doi.org/10.7554/eLife.86971
Gibson, S.V., Tomas Bort, E., Rodríguez-Fernández, L. et al. TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression. npj Breast Cancer 9, 9 (2023). https://doi.org/10.1038/s41523-023-00513-6
Clayton, K., Holbrook, D. J., Vallejo, A. et al. Skin programming of inflammatory responses to Staphylococcus aureus is compartmentalized according to epidermal keratinocyte differentiation status, British Journal of Dermatology, Volume 188, Issue 3, March 2023, Pages 396–406, https://doi.org/10.1093/bjd/ljac088
Davies CR, Guo T, Burke E, Stankiewicz E et al. The potential of using circulating tumour cells and their gene expression to predict docetaxel response in metastatic prostate cancer. Front. Oncol. 12:1060864 (2023). doi: 10.3389/fonc.2022.1060864