Cancer | Enhancing oncolytic adenovirus efficacy for the treatment of metastatic prostate cancer through combination with BET protein inhibitors | Yong-Jie Lu | Barts Cancer Institute | 2019 | MRC-DTP |
Cancer | Understanding the impact of cannabinoid 2 receptor modulation on HER2-positive tumour growth | Richard Grose | Barts Cancer Institute | 2023 | MRC iCASE |
Cancer | Engineering bacteria to sensitize immuneexcluded TNBC to CAR-T Cell therapy | Oliver Pearce | Barts Cancer Institute | 2021 | MRC iCASE |
Cancer | Investigating the direct crosstalk between NK cells, cancer-associated fibroblasts (CAFs) and monocytes in the onset of TNBC lung metastasis | Luigi Ombrato | Barts Cancer Institute | 2020 | MRC-DTP |
Cancer | Whole genome CRISPR screens to map genetic determinants of radionuclide therapy of cancer | Jane Sosabowski | Barts Cancer Institute | 2024 | MRC iCASE |
Cancer | Characterising the metabolic requirements of the newly identified DC3 subset | Katiuscia Bianchi | Barts Cancer Institute | 2022 | MRC iCASE |
Cancer | Developing Models to Understand the Impact of Chromosome Instability on Therapy Resistance in Ovarian Cancer | Sarah McClelland | Barts Cancer Institute | 2019 | MRC-DTP |
Cancer | Dysregulation of cGAS-STING Signalling in High Grade Serous Ovarian Cancer | Sarah McClelland | Barts Cancer Institute | 2021 | MRC-DTP |
Cancer | Investigating the metabolic regulation of conventional dendritic cells and how it is influenced by different tissue environments and activation states | Katiuscia Bianchi | Barts Cancer Institute | 2018 | MRC-DTP |
Cancer | Understanding the T cell antigen presentation landscape in gastro-oesophageal cancers with oncogene amplification | Marco Gerlinger | Barts Cancer Institute | 2022 | MRC-DTP |
Cancer | Signal Rewiring of the DNA Damage Pathway in Cancer | Tanya Soliman | Barts Cancer Institute | 2022 | MRC-DTP |
Cancer | Computational analysis of transcriptomic data to identify PTEN-loss associated alternative splicing (AS) derived neoantigens in cancer datasets | Prabhakar Rajan | Barts Cancer Institute | 2020 | MRC-DTP |
Cancer | Investigating and Targeting EGFR Heterogeneity in Glioblastoma | Paulo Baptista-Ribeiro | Barts Cancer Institute | 2023 | MRC iCASE |
Cancer | Purification and characterization of micronuclei | Sarah McClelland | Barts Cancer Institute | 2022 | MRC iCASE |
Cancer | Establishing NIPBL as a Novel Biomarker in Triple Negative Breast Cancer | Barrie Peck | Barts Cancer Institute | 2020 | MRC-DTP |
Cancer | Validating a novel synthetic lethality in LIMD1 deficient lung cancers | Tyson Sharp | Barts Cancer Institute | 2021 | MRC-DTP |
Cancer | Understanding the effect of chemotherapy on tumour heterogeneity and plasticity in colorectal cancer metastases | Mirjana Efremova | Barts Cancer Institute | 2021 | MRC-DTP |
Cancer | Interrogating the high grade serous ovarian cancer tumour microenvironment during the evolution of resistance to cancer drug therapy | Michelle Lockley | Barts Cancer Institute | 2023 | MRC-DTP |
Cancer | Study of genetic and immunological events in Lynch syndrome progression to colorectal cancer | Stuart McDonald | Barts Cancer Institute | 2018 | MRC-DTP |
Cancer | Investigating the role of POSTN in therapy resistance in TNBC via recruitment of pro-tumoral macrophages | Oliver Pearce | Barts Cancer Institute | 2021 | MRC-DTP |
Cancer | Dissecting cannabinoid receptor 2 signalling in HER2+ breast cancer | Richard Grose | Barts Cancer Institute | 2022 | MRC-DTP |
Cancer | Pro-senescence therapies for basal-like breast cancer | Cleo Bishop | Blizard | 2019 | MRC-DTP |
Cancer | Cancer associated fibroblasts in squamous cancer: Coupling transcriptional heterogeneity with pathological matrix dynamics | Emanuel Rognoni | Blizard | 2023 | MRC-DTP |
Cancer | Investigating rDNA dysregulation in cancer: Unraveling chromosomal rearrangements and breakage consequences on rDNA activity, ribosome biogenesis, and oncogenic transformation | Vardhman Rakyan | Blizard | 2023 | MRC-DTP |
Immunity & Infection | Characterising host-pathogen interactions in haematopoietic stem cells isolated from blood & bone marrow of adults with latent tuberculosis infection | Adrian Martineau | Blizard | 2024 | MRC iCASE |
Enteric Neurobiology | Clinical validation of a novel, nutritional treatment to induce weight loss in obese volunteers and Type 2 diabetic patients | Madusha Peiris | Blizard | 2023 | MRC iCASE |
Immunity & Infection | Investigating the Mechanisms of Autoimmunity induced by Epstein-Barr Virus in Early Multiple Sclerosis | Angray Kang | Institute of Dentistry | 2022 | MRC-DTP |
Cancer Immunology | Investigate the immunoregulatory role of Keratin 76 in the thymus, focusing particularly at the crosstalk between thymic epithelial cells and T cells, and how loss of Keratin 76 is affecting T cell development/maturation. | Inês Sequeira | Institute of Dentistry | 2020 | MRC-DTP |
Neurodegenerative diseases | Exploring the links between dementia and cardiovascular diseases: causal interference and early detection | Petroula Proitsi | Wolfson Institute | 2023 | MRC-DTP |