MRC DTP BIOMED

Current PhD Projects

The table below lists all current PhD/iCASE projects at QMUL sponsored by both the MRC DTP. As 1st year PhD students undergo MRes training with three rotational projects, these are not listed here.

Research ThemePhD Project TitlePhD SupervisorInstituteCohort Start DateFunding
CancerEnhancing oncolytic adenovirus efficacy for the treatment of metastatic prostate cancer through combination with BET protein inhibitorsYong-Jie LuBarts Cancer Institute2019MRC-DTP
CancerUnderstanding the impact of cannabinoid 2 receptor modulation on HER2-positive tumour growthRichard GroseBarts Cancer Institute2023MRC iCASE
CancerEngineering bacteria to sensitize immuneexcluded TNBC to CAR-T Cell therapyOliver PearceBarts Cancer Institute2021MRC iCASE
CancerInvestigating the direct crosstalk between NK cells, cancer-associated fibroblasts (CAFs) and monocytes in the onset of TNBC lung metastasisLuigi OmbratoBarts Cancer Institute2020MRC-DTP
CancerWhole genome CRISPR screens to map genetic determinants of radionuclide therapy of cancerJane SosabowskiBarts Cancer Institute2024MRC iCASE
CancerCharacterising the metabolic requirements of the newly identified DC3 subsetKatiuscia BianchiBarts Cancer Institute2022MRC iCASE
CancerDeveloping Models to Understand the Impact of Chromosome Instability on Therapy Resistance in Ovarian CancerSarah McClellandBarts Cancer Institute2019MRC-DTP
CancerDysregulation of cGAS-STING Signalling in High Grade Serous Ovarian CancerSarah McClellandBarts Cancer Institute2021MRC-DTP
CancerInvestigating the metabolic regulation of conventional dendritic cells and how it is influenced by different tissue environments and activation statesKatiuscia BianchiBarts Cancer Institute2018MRC-DTP
CancerUnderstanding the T cell antigen presentation landscape in gastro-oesophageal cancers with oncogene amplificationMarco GerlingerBarts Cancer Institute2022MRC-DTP
CancerSignal Rewiring of the DNA Damage Pathway in CancerTanya SolimanBarts Cancer Institute2022MRC-DTP
CancerComputational analysis of transcriptomic data to identify PTEN-loss associated alternative splicing (AS) derived neoantigens in cancer datasetsPrabhakar RajanBarts Cancer Institute2020MRC-DTP
CancerInvestigating and Targeting EGFR Heterogeneity in GlioblastomaPaulo Baptista-RibeiroBarts Cancer Institute2023MRC iCASE
CancerPurification and characterization of micronucleiSarah McClellandBarts Cancer Institute2022MRC iCASE
CancerEstablishing NIPBL as a Novel Biomarker in Triple Negative Breast CancerBarrie PeckBarts Cancer Institute2020MRC-DTP
CancerValidating a novel synthetic lethality in LIMD1 deficient lung cancersTyson SharpBarts Cancer Institute2021MRC-DTP
CancerUnderstanding the effect of chemotherapy on tumour heterogeneity and plasticity in colorectal cancer metastasesMirjana EfremovaBarts Cancer Institute2021MRC-DTP
CancerInterrogating the high grade serous ovarian cancer tumour microenvironment during the evolution of resistance to cancer drug therapyMichelle LockleyBarts Cancer Institute2023MRC-DTP
CancerStudy of genetic and immunological events in Lynch syndrome progression to colorectal cancerStuart McDonaldBarts Cancer Institute2018MRC-DTP
CancerInvestigating the role of POSTN in therapy resistance in TNBC via recruitment of pro-tumoral macrophagesOliver PearceBarts Cancer Institute2021MRC-DTP
CancerDissecting cannabinoid receptor 2 signalling in HER2+ breast cancerRichard GroseBarts Cancer Institute2022MRC-DTP
CancerPro-senescence therapies for basal-like breast cancerCleo BishopBlizard2019MRC-DTP
CancerCancer associated fibroblasts in squamous cancer: Coupling transcriptional heterogeneity with pathological matrix dynamicsEmanuel RognoniBlizard2023MRC-DTP
CancerInvestigating rDNA dysregulation in cancer: Unraveling chromosomal rearrangements and breakage consequences on rDNA activity, ribosome biogenesis, and oncogenic transformationVardhman RakyanBlizard2023MRC-DTP
Immunity & InfectionCharacterising host-pathogen interactions in haematopoietic stem cells isolated from blood & bone marrow of adults with latent tuberculosis infectionAdrian MartineauBlizard2024MRC iCASE
Enteric NeurobiologyClinical validation of a novel, nutritional treatment to induce weight loss in obese volunteers and Type 2 diabetic patientsMadusha PeirisBlizard2023MRC iCASE
Immunity & InfectionInvestigating the Mechanisms of Autoimmunity induced by Epstein-Barr Virus in Early Multiple SclerosisAngray KangInstitute of Dentistry2022MRC-DTP
Cancer ImmunologyInvestigate the immunoregulatory role of Keratin 76 in the thymus, focusing particularly at the crosstalk between thymic epithelial cells and T cells, and how loss of Keratin 76 is affecting T cell development/maturation.Inês SequeiraInstitute of Dentistry2020MRC-DTP
Neurodegenerative diseasesExploring the links between dementia and cardiovascular diseases: causal interference and early detectionPetroula ProitsiWolfson Institute2023MRC-DTP