Below is a list of recent publications in which students of our DTP have been involved. The complete list can be found in the left panel of this page.
Ogden S, Metic N, Leylek O, Smith EA, et al. Phenotypic heterogeneity and plasticity in colorectal cancer metastasis. Cell Genomics,
2025. https://doi.org/10.1016/j.xgen.2025.100881.
Zhao Z, Cutmore LC, Baleeiro RB, Hartlebury JJ, Brown N, Chard-Dunmall L, Lemoine N, Wang Y, Marshall JF. The Combination of Oncolytic Virus and Antibody Blockade of TGF-β Enhances the Efficacy of αvβ6-Targeting CAR T Cells Against Pancreatic Cancer in an Immunocompetent Model. Cancers. 2025; 17(9):1534. https://doi.org/10.3390/cancers17091534
Hilary A. Kenny, Carman Ka Man Ip, Lucy Kelliher, et. al.; Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth. Mol Cancer Ther 2025; https://doi.org/10.1158/1535-7163.MCT-23-0863
Rodriguez-Algarra T, Whittaker E, del Castillo del Rio S, K. Rakyan V. Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes. BioEssays 2025 Apr;47(4):e202400232. doi: 10.1002/bies.202400232.
Alves Martins R, Tekin MM, Cragg MS, Roghanian A. Therapeutic targeting of tumour-associated macrophage receptors, Immunotherapy Advances, 2025; ltaf009, https://doi.org/10.1093/immadv/ltaf009
Dawson, L.E., Sekar, A., Fulford, A.D. et al. The deubiquitylating enzyme Fat facets promotes Fat signalling and restricts tissue growth. Nat Commun 16, 1938 (2025). https://doi.org/10.1038/s41467-025-57164-3
Parkin, JGH, Dean, LSN, Bell, JA et al. Copper-enriched automotive brake wear particles perturb human alveolar cellular homeostasis. Part Fibre Toxicol 22, 4 (2025). https://doi.org/10.1186/s12989-024-00617-2
Savy T, Flanders L, Karpanasamy T et al.. Cancer evolution: from Darwin to the Extended Evolutionary Synthesis. Trends in Cancer. 2025; https://doi.org/10.1016/j.trecan.2025.01.001
Valero-Hernandez E, Tremoleda JL, Michael-Titus AT. Omega-3 Fatty Acids and Traumatic Injury in the Adult and Immature Brain. Nutrients. 2024; 16(23):4175. https://doi.org/10.3390/nu16234175
Ermogenous C, Ombrato L, Beattie G. Abstract B022: Investigating how monocytes impair NK cell cytotoxicity in lung metastasis of triple-negative breast cancer. Cancer Res 15 November 2024; 84 (22_Supplement): B022. https://doi.org/10.1158/1538-7445.TUMBODY-B022
Tarantola L, Keklikoglou I, Pearce OM. Abstract C045: The extracellular matrix glycoprotein periostin supports chemotherapy resistance by modulating macrophage recruitment and phagocytosis in triple negative breast cancer. Cancer Res 15 November 2024; 84 (22_Supplement): C045. https://doi.org/10.1158/1538-7445.TUMBODY-C045
Sofia C, Edgeway L, Parkin J et al. The effect of air pollution on the antiviral immune response in pulmonary fibrosis. European Respiratory Journal 2024 64(suppl 68): PA4453; DOI: https://doi.org/10.1183/13993003.congress-2024.PA4453
O’Sullivan, E.A., Wallis, R., Mossa, F. et al. The paradox of senescent-marker positive cancer cells: challenges and opportunities. npj Aging 10, 41 (2024). https://doi.org/10.1038/s41514-024-00168-y
Carr, L., Norris, K., Parker, H., Nilsson-Takeuchi, A. et al. Telomere length and DNA methylation epitype both provide independent prognostic information in CLL patients; data from the UK CLL4, ARCTIC and ADMIRE clinical trials. Br J Haematol (2024). https://doi.org/10.1111/bjh.19765
Graham LV, Fisher JG, Doyle ADP, Sale B, Del Rio L, French AJE, Mayor NP, Turner TR, Marsh SGE, Cragg MS, Forconi F, Khakoo SI and Blunt MD. KIR2DS2+ NK cells in cancer patients demonstrate high activation in response to tumour-targeting antibodies. Front. Oncol. (2024). 14:1404051. doi: 10.3389/fonc.2024.1404051
Bell, J.A., Davies, E.R., Brereton, C.J., et al. Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2, Cell Reports Medicine 5, 9 (2024). https://doi.org/10.1016/j.xcrm.2024.101695
Hill BR, Ozgencil M, Buckley-Benbow L, Skingsley SLP, Tomlinson D, Eizmendi CO, Agnarelli A, Bellelli R. Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors. Cell Rep. 2024 May 28;43(5):114205. doi: 10.1016/j.celrep.2024.114205.
Dontamsetti KD, Pedrosa-Suarez LC, Aktar R, Peiris M. Sensing of luminal contents and downstream modulation of GI function. JGH Open. 2024 May 22;8(5):e13083. doi: 10.1002/jgh3.13083.
Guscott, M.A., McClelland, S.E. Experimental evolution of cancer chromosomal changes. Nat Genet (2024). https://doi.org/10.1038/s41588-024-01742-6
Kafka A, Ermogenous C, Ombrato L (2024). Isolation of Live Immune Cells from the Tumor Microenvironment by FACS. In: Siciliano, V., Ceroni, F. (eds) Cancer Immunotherapy. Methods in Molecular Biology, vol 2748. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3593-3_1
Graham LV, Fisher JG, Khakoo SI, Blunt MD. Targeting KIR as a novel approach to improve CAR-NK cell function. Journal of Translational Genetics and Genomics. 2023; 7(4): 230-5. http://dx.doi.org/10.20517/jtgg.2023.25
Fu, H., Vuononvirta, J., Fanti, S. et al. The glucose transporter 2 regulates CD8+ T cell function via environment sensing. Nat Metab 5, 1969–1985 (2023). https://doi.org/10.1038/s42255-023-00913-9
Andrade, J.R., Gallagher, A.D., Maharaj, J. et al. Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies. Chromosome Res 31, 28 (2023). https://doi.org/10.1007/s10577-023-09737-5
Elhassan YS, Appenzeller S., Landwehr LS, Lippert J, Popat D et al. Primary unilateral macronodular adrenal hyperplasia with concomitant glucocorticoid and androgen excess and KDM1A inactivation, European Journal of Endocrinology, Volume 191, Issue 3, September 2024, Pages 334–344, https://doi.org/10.1093/ejendo/lvae106
Ramakrishnan A, Popat D, Purushothaman P, Chan LF, Gevers EF. A Novel Maternally Inherited GNAS Variant in a Family With Hyperphagia and Obesity: 3 Cases, JCEM Case Reports, Volume 2, Issue 8, August 2024, luae125, https://doi.org/10.1210/jcemcr/luae125
Fisher, J.G., Doyle, A.D.P., Graham, L.V. et al. XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression. Leukemia 37, 2036–2049 (2023). https://doi.org/10.1038/s41375-023-01984-z
Lawrence, R., Watters, M., Davies, C.R. et al. Circulating tumour cells for early detection of clinically relevant cancer. Nat Rev Clin Oncol 20, 487–500 (2023). https://doi.org/10.1038/s41571-023-00781-y
Sirvent, S., Vallejo, A.F., Corden, E. et al. Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis. Nat Commun 14, 2880 (2023). https://doi.org/10.1038/s41467-023-38588-1
Puttock, E.H., Tyler, E.J., Manni, M. et al. Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis. Nat Commun 14, 2514 (2023). https://doi.org/10.1038/s41467-023-38093-5
Relton, E.l., Roth, N.J., Yasa, S., Lefrancois, S., McCormick, P.J., Locker, N. et al. The Batten disease protein CLN3 is important for stress granules dynamics and translational activity. Journal of Biological Chemistry 299, 104649 (2023). https://doi.org/10.1016/j.jbc.2023.104649